Hepatocarcinoma

https://ejnmmipharmchem.springeropen.com/articles/10.1186/s41181-019-0066-3. Intrahepatic visualisation of Ho-166-microspheres after SIRT. T2-weighted MRI of the liver in a patient with several ocular melanoma liver metastases, outlined by coloured regions of interest (a). After SIRT, the distribution of Ho-166-PLLA-microspheres within the liver was visualized by single-Photon-emission CT (b) and R2-weighted MRI (c). Reprinted from The Lancet Oncology, Vol. 13, Smits et al., Holmium 166 SIRT in patients with unresectable, chemorefractory liver metastases (HEPAR trial): a phase 1, dose-escalation study, 1025–1034, Copyright 2012, with permission from Elsevier.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults.

The proposed treatments are of limited effectiveness and show little progress. Radioembolization using Lipiodol labeled with iodine-131 (131I) or rhenium-188 (188Re) and microspheres (glass or resin) labeled with yttrium-90 (90Y) is promising but under-used. The more recent developments with microspheres allow a significant Irradiation of the tumors without notable Irradiation of the neighboring liver with an excellent efficiency and little toxicity.

Sources: NIH.gov, Sciencedirect.com