SNMMI Image of the Year 2022: PET/CT Biomarker Predicts Post-MI Cardiac Remodeling

Journal of Nuclear medicine July 2022, 63 (7) 16N;

Chosen from more than 1, 280 submitted scientific abstracts and voted on by reviewers and society leadership, the SNMMI 2022 Image of the Year is the image from Diekmann et al. from the Hannover Medical School (Germany) showing contrasted 68Ga–fibroblast-activation protein–46 (68Ga-FAP-46) PET/CT, 99mTc-tetrofosmin perfusion SPECT, and cardiac MR images acquired in patients within 11 days after acute myocardial infarction.

Top: Representative case with acute anterior wall myocardial infarction. 99mTc-tetrofosmin perfusion SPECT, 68Ga–fibroblast-activation protein–46 (68Ga-FAP-46) PET/CT, and late gadolinium-enhanced (LGE) cardiac MR images were compared in patients within 11 days after acute myocardial infarction. Bottom: Areas of myocardial FAP upregulation on PET/CT were significantly greater than those with either SPECT or MRI and were predictive of subsequent left ventricular (LV) dysfunction. Global myocardial FAP volume early after acute myocardial infarction inversely correlated with left ventricular ejection fraction (LVEF) at follow-up in the chronic stage. The findings suggest promise for 68Ga-FAP-46 PET/CT as a complementary biomarker in predicting adverse cardiac remodeling.

© 2022 by the Society of Nuclear medicine and Molecular Imaging.

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