I-131 Tositumomab (Bexxar®)


131I-Tositumomab (Bexxar®) is an anti-CD20 antibody developed and launched by GlaxoSmithKline in 2003 for the treatment of non-Hodgkin lymphoma (NHL). The compound had been initially developed by Corixa (formerly Coulter Pharmaceutical, now GlaxoSmithKline GSK). Bexxar has been approved in the US since 2003 and Canada since 2005. Bexxar was never launched in Europe.

Bexxar was discontinued and marketing approval withdrawn on February 20, 2014 following the failure to demonstrate in 2011 a clinical benefit over CHOP chemotherapy plus Rituxan (rituximab) in patients with newly diagnosed follicular NHL. This resulted in the decline in usage.

131I-Tositumomab is indicated for the treatment of patients with CD20 antigen-expressing relapsed or refractory, low-grade, follicular or transformed NHL, including patients with Rituximab-refractory non-Hodgkin’s lymphoma.

It seems that private investors are considering relaunching this drug however no more information is available at this time.