Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. These cancers presented challenges in new drug development partly because of their rarity and heterogeneity. Many new molecular targeting drugs have been tried in the 2010s, and some were approved for bone and soft tissue sarcoma.
The skeleton is a potential metastatic target of many malignant tumors. Up to 85% of prostate and breast cancer patients may develop bone metastases causing severe pain syndromes in many of them. Radionuclide therapy is recommended for pain palliation. The therapy is repeatable, depending on cell counts. Clinical trials using Radium-223 and/or combinations of chemotherapy and radionuclides are aiming at a more curative approach.