⁹⁰Y-FAPi-46 is the therapeutic analogue of the PET Imaging agent ⁶⁸Ga-FAPi-46 from the FAPi family developed at the Cancer Research Center of Heidelberg, Germany. It is a radiotherapeutic agent based on a Fibroblast Activation Protein (FAP)-specific enzyme inhibitor (FAPi), to be found on almost all solid tumors. The first clinical Dosimetry trial was performed at University Hospital Essen, Germany.
FAPis target cancer-associated fibroblasts (CAFs), yielding images with similar or better quality compared with ¹⁸F-FDG-PET/CT among patients with cancer and the ⁹⁰Y-labeled analogue can find applications as therapeutics for these same patients. Besides cancer, FAPis may also be used for benign diseases such as fibroses, Atherosclerosis, rheumatoid arthritis, sarcoidosis, etc.

Target/Mechanism: Fibroblasts

Carrier/Ligand: FAPI-46

Radiation Type: beta electrons (β–)