90Y-Carbon microspheres are a new form of microspheres based on carbon microparticles with embedded 90Y, developed in China with indication similar to already marketed other micropheres (SIRSpheres, TheraSpheres or QuiremSpheres) based microspheres.
90Y-microspheres are approved for a larger number of indications (depending upon the territories). These indications, described with the acronym SIRT for Selective Internal Radio-Therapy, include all metastasized tumors that spread to the liver. Data are available for use in hepatocellular carcinoma (HCC) and liver metastases of colorectal, neuroendocrine tumors, breast, and ocular melanoma tumors, as well as liver metastases of cholangiocarcinoma and a series of different primary cancers for which no large, specific clinical trials have been performed. In all these indications, this product has shown significant increase in overall survival (up to several years), but not full cure.
In this specific case, carbon microspheres are first evaluated in patients with liver metastases provided from primary colon cancers.

Target/Mechanism: Brachytherapy

Carrier/Ligand: n/a

Radiation Type: beta electrons (β–)