177Lu-TLX250 (177Lu-Lutarex®, 177Lu-Girentuximab), a Lutetium-177-labeled monoclonal antibody is being developed as a potential RIT for various cancers including renal cell carcinoma (RCC). 177Lu-cG250’s development became an extension of the development of the imaging agent 124I-Girentuximab (124I-Redectane®).
G250 (Girentuximab) is a chimeric murine human monoclonal antibody which targets the Carbonic Anhydrase IX (CA-IX) molecule/G250 antigen, expressed on over 90% of clear cell renal cell carcinomas.
A Phase I/II safety and efficacy trial with 177Lu-cG250 was initiated in February 2005 in patients with advanced RCC. The dosimetry was determined using 111In-cG250. A Phase II efficacy study was initiated in 2013 in patients with advanced clear cell kidney cancer. The study demonstrated stability in about 75% of the patients.
The development of this molecule is now progressing in a fast way (Phase II) and the diagnostic agent could reach the market by 2023.
Radiation Type: beta electrons (β–)