177Lu-RM2 (177Lu-BAY-1017858) is a molecule corresponding to a different than PSMA biological approach for treating prostate cancer developed originally at Bayer. Unfortunately, it does not seem this molecule is presently supported by a private group, but some research was reactivated in 2020.

177Lu-RM2 efficiently targets the BB2r (Bombesin receptor 2) expressed on CRPC cells in vivo. This molecule is associated to the diagnostic agent 68Ga-Bombesin (68Ga-RM2).

Target/Mechanism: GRPR

Carrier/Ligand: Bombesin

Radiation Type: beta electrons (β)

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