203Pb-DOTA-VMT-MCR1 (203Pb-VMT01) and the therapeutic analogue 212Pb-VMT01 are labeled peptides that bind with high affinity and specificity to MCR1. They are developed for targeted imaging and image-guided therapy of metastatic melanoma by the US Company Viewpoint Molecular Targeting, LLC in partnership with RadioMedix.
For imaging purpose, the company is also developing the analogue 68Ga-VMT02.
203Pb-DOTA-VMT-MCR1 binds with high affinity and specificity to melanocortin receptor subtype I (MC1R) and can be used for targeted imaging and image-guided therapy of metastatic melanomas. MC1R is upregulated at the surface of metastatic melanoma cells. A phase I study was initiated in May 2021.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.