With some radiopharmaceuticals now used in clinical practice, somatostatin analogs developed for Imaging and therapy are an example of the concept of personalized medicine with a Theranostic approach. Here, we review the development of these analogs, from the well-established and authorized ones to the most recently developed radiotracers, which have better pharmacokinetic properties and demonstrate increased efficacy and safety, as well as the search for new clinical indications