Melanoma is a type of skin cancer that develops when melanocytes (the cells that give the skin its tan or brown color) start to grow out of control. Melanoma is much less common than some other types of skin cancers. But melanoma is more dangerous because it is much more likely to spread to other parts of the body if not caught and treated early. In recent years, there has been a dramatic worldwide increase in incidence of melanoma.
Early-stage melanomas can often be treated with surgery alone, but more advanced cancers often require other treatments. Sometimes more than one type of treatment is used. Promising results based on systemic radionuclide therapy represent a novel approach for the therapy of malignant melanoma and are of considerable potential. Intralesional Targeted Alpha Therapies (TAT) for melanoma clinical trials was found to be efficacious and a promising therapy for the control of inoperable secondary melanoma or primary ocular melanoma.