186Re-Rhenium Colloidal Sulfide is a generic treatment used for isotopic radiation synovectomy of medium size joints.
186Re-Rhenium Colloidal Sulfide is used in the treatment of rheumatoid mono- or oligo-arthritis involving medium-sized joints (shoulders, elbow, wrists, ankles, hips) and particularly polyarthritis. It is also useful in the treatment of hemophilic or chronic arthropathy associated with articular chondrocalcinosis. The suspension is injected in each painful joint which is kept in a fixed position for a few hours or days to avoid the escape of the radioactive substance from the injected joints. The reduction of extra-articular escape is the major issue in this modality but is now well controlled.
The maximum tissue penetration for 186Re in radiosynoviorthesis applications is estimated at 4.4 mm.