Re-186-Rhenium Etidronate (HEDP)

Re-186

186Re-Rhenium Etidronate (186Re-HEDP, hydroxyethylidene diphosphonate) was developed for use in relieving the pain associated with metastatic bone cancer. The formulation had been approved and launched in Switzerland and Greece, but the NDA submitted to the US FDA was never approved and the project was discontinued in the US. Eventually the product was also withdrawn from the EU countries. In developing countries generic copies found some interest (mainly because established competitors with IP were too expensive) and the drug is still available outside of the EU and US.

186Re-HEDP is indicated for bone pain palliation in cancer metastases (prostate, breast). Doses per patient are about 35 mCi.